Fig. 4: Path diagram, Manhattan, and PheWAS plot for common physical illness factor.
From: Shared Genetic Liability across Systems of Psychiatric and Physical Illness
A Single-headed arrows represent regression paths and curved double-headed arrows represent residual genetic variance components. The outer circles with arrows pointing to each indicator represent indicator residual variances, with the corresponding value and SE presented in each circle. AHS abnormal heart sounds, CCD cardiac conduction disorders, HFA heart failure, PVD peripheral vascular disease, APA acute pancreatitis, CON constipation, DES diseases of the esophagus, DYS dysphagia, GAD gastritis & duodenitis, GIH gastrointestinal hemorrhage, PCE peptic ulcer excl. esophageal, IDD intervertebral disc disorders, PEA peripheral enthesopathies & allied syndromes, SAD spondylosis & allied disorders, CAO chronic airway obstruction, PNE pneumonia, RAB respiratory abnormalities, NPD nerve, root, and plexus disorders, SLD sleep disorders, HEM hematuria, UTI urinary tract infection. B Manhattan plot for multivariate GWAS of common physical disease factor estimated with Genomic SEM. The chromosomes are displayed on the x-axis, and the −log10 p-values for the association between each SNP and the physical illness factor are displayed on the y-axis. The dashed gray line denotes the two-sided genome-wide significance threshold of 5 × 10−8. C PheWAS plot for common physical disease factor conducted in Penn Medicine Biobank with LDpred2. The x-axis depicts the respective system for each EHR-derived phenotype, with −log10 p-values displayed on the y-axis. All significance testing was two-sided. The triangles display the direction of effect (e.g., upwards triangles for positive and downwards triangles for negative).
