Fig. 5: Inter-factor relationships between the common physical factor and the psychiatric factors.
From: Shared Genetic Liability across Systems of Psychiatric and Physical Illness
Inter-factor genetic correlations between the common disease factor (expected sample size \(\hat{[N]}\) = 106,118.7) and five psychiatric factors estimated with Genomic SEM. All relationships were significant at a Bonferroni-corrected significance threshold of p < 5.6 \(\times {10}^{-4}\) (0.05/110 inter-factor genetic correlations) with orange bars depicting significant QFactor results at the same threshold. Error bars depict ±95% confidence intervals. Data S7 and S8, respectively, contain sample size and study information for physical and psychiatric disorders analyzed in this plot. Comp compulsive (p = 1.48E − 2), Psych psychotic/thought (p = 3.69E − 9), Neuro neurodevelopmental (p = 9.51E − 41), Int internalizing (p = 4.61E − 92), SUD substance-use disorders (p = 1.57E − 45).
