Fig. 6: Alpha-like oscillations are linked to differential activity of PV+ and SOM+ GABAergic interneurons.
From: A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1-/y mice
a Inset: Experimental design. V1 L4 LFP data were collected in head-fixed PV-Cre mice (p50–80, n = 16) with chemogenetic actuator hM4Di expressed in V172, viewing a static, iso-luminant gray screen. Main: Absolute power spectrum (mean +/− SEM) from 150 seconds of data before (black) and after (purple) systemic injection of CNO. Notch filter 45-75 Hz. b Aperiodic fit (mean +/− SEM). c−e Boxplot and FDR-corrected p-values for: c Aperiodic offset (uncorrected p-value = 1.6e−3, z-statistic = −3.15, effect size = −0.775); d Aperiodic slope (uncorrected p-value = 4.38e−4, z-statistic = −3.5216, effect size = −1); and e Aperiodic knee frequency (z-statistic = −2.896, effect size = −0.55). f Main: Periodic power (mean +/− SEM). Inset: Peak 1 (Pk1) with higher spectral resolution. g−j Boxplot and FDR-corrected p-values for: g Pk1a center frequency. Z-statistic = −0.487, effect size = −0.046; h Pk1a maximum power. Uncorrected p-value = 0.234, z-statistic = −1.189, effect size = −0.258; i Pk1b center frequency. Uncorrected p-value = 0.278, z-statistic = −1.086, effect size = −0.167; and j Pk1b maximum power. Uncorrected p-value = 1.9e−3, z-statistic = 3.103, effect size = 0.858. k–t Same as a–j but for SOM-Cre mice (p50-70) expressing either an inhibitory opsin virus (NpHR3, n = 8) or empty viral vector (EV, n = 7) in V1. Power spectra derived from ‘laser on’ periods. For m, uncorrected p-value = 0.232; o uncorrected p-value = 0.397; q uncorrected p-value = 0.408; s uncorrected p-value = 0.02; and t uncorrected p-value = 0.12. Dots at the bottom of plots in (a, b, f, k, p) indicate the points of significant difference between groups (non-parametric hierarchical bootstrap, 99% confidence interval). Boxplots show 25th, median, and 75th percentiles, with whiskers extending to minimum and maximum values. In (c–e, g–j), uncorrected p-values and z-statistics calculated from two-sample, two-sided Wilcoxon Signed-Rank Tests, and effect sizes calculated using Cliff’s Delta. In (m–o, q–t), uncorrected p-values calculated from two-sample, two-sided Wilcoxon Rank-Sum Tests. Z-statistics and effect sizes not calculated for n < 10. P-values adjusted with the Benjamini-Hochberg correction. Source data are provided as a Source Data file.
