Fig. 4: Antiviral activity of degrader candidates depends on the targeted degradation of the capsid. | Nature Communications

Fig. 4: Antiviral activity of degrader candidates depends on the targeted degradation of the capsid.

From: Degraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors

Fig. 4: Antiviral activity of degrader candidates depends on the targeted degradation of the capsid.

a Viral plaque assays quantifying infectious progeny virus in cell culture supernatants corresponding to the experiments depicted in Fig. 3a. Antiviral EC50 values were determined by nonlinear regression analysis using data from three independent biological experiments (n = 3) for RPG-01-139 and RPG-01-132 in wild-type cells. All other conditions were assessed in two independent biological experiments (n = 2) and are shown for comparison. Data are presented as mean viral titers normalized to DMSO; error bars represent standard deviation. b Antiviral activity of RPG-01-139 and RPG-01-132 in the presence or absence of the neddylation inhibitor MLN4924 (1.25 µM). Data shown are from two independent biological experiments and are presented as means ± standard deviation, normalized to DMSO. No statistical analyses were performed due to the limited number of biological replicates (n = 2). Source data are provided as a Source Data file.

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