Fig. 6: Risk of dementia and negative control outcomes among two-dose RZV-vaccinated versus unvaccinated individuals. | Nature Communications

Fig. 6: Risk of dementia and negative control outcomes among two-dose RZV-vaccinated versus unvaccinated individuals.

From: Recombinant zoster vaccine is associated with a reduced risk of dementia

Fig. 6: Risk of dementia and negative control outcomes among two-dose RZV-vaccinated versus unvaccinated individuals.

Incidence of dementia and negative control outcomes with 95% confidence intervals and adjusted hazard ratios with 95% confidence intervals calculated using a Cox regression model with IPTW are presented for two-dose RZV-vaccinated (n = 65,800) compared to unvaccinated (n = 263,200) individuals. aAdjusted for time-varying vaccination status (influenza, COVID-19, and other vaccines) besides IPTW. bWrist fracture included as a negative control outcome recommended in Salmon DA, et al. J Infect Dis. 2023;11:1224-1226. cComposite negative control outcome modeled from Taquet M et al. Nature Medicine. 2024;30:2777-2781. dUpper bound of the confidence interval is 0.998. aHR adjusted hazard ratio, CI confidence interval, IPTW inverse probability of treatment weighting, n number, RZV recombinant zoster vaccine.

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