Fig. 7: 8803 exerts a therapeutic effect across orthotopic preclinical meningioma models. | Nature Communications

Fig. 7: 8803 exerts a therapeutic effect across orthotopic preclinical meningioma models.

From: STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways

Fig. 7: 8803 exerts a therapeutic effect across orthotopic preclinical meningioma models.

A Schematic of orthotopic treatment experiments in immunocompromised mice created with BioRender. B Survival of nude mice orthotopically implanted with IOMM-Lee using Kaplan-Meier analysis. Controls: n = 10 mice (median survival [MS]: 24.5 days), 8803: n = 9 mice (MS: 34 days). Statistics (log-rank test): control versus 8803, P = 0.0125. C Survival of nude mice orthotopically implanted with CH157-MN using Kaplan-Meier analysis. The remaining mice were terminated at day 150. Controls: n = 10 mice (MS: 16 days), 8803: n = 10 mice (MS: 45 days). Statistics (log-rank test): control versus 8803, P = 0.00005.

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