Table 3 Outcomes of ovarian stimulation

From: Transdermal testosterone gel vs placebo in women with diminished ovarian reserve prior to in vitro fertilization: a randomized, clinical trial

Outcome

Testosterone

(N = 134)

Placebo

(N = 154)

Mean difference (95% CI)

P value

Duration of stimulation — d

11.5 ± 2.8

11.7 ± 2.2

−0.18 (−0.88 to 0.52)

0.61

Total gonadotropin dose — IU

3458 ± 819

3507 ± 631

−48 (−252 to 154)

0.63

No. of oocytes retrieved

3.8 ± 2.7

3.4 ± 2.3

0.34 (−0.36 to 1.0)

0.34

No. of MII oocytes retrieved

3.1 ± 2.4

2.8 ± 2.1

0.23 (−0.40 to 0.86)

0.46

No. of MII oocytes inseminated

3.0 ± 2.4

2.7 ± 2.1

0.31 (−0.32 to 0.93)

0.34

No. of 2PN zygotes

2.2 ± 2.0

1.8 ± 1.4

0.38 (−0.11 to 0.87)

0.14

No. of D3 embryos

1.9 ± 1.9

1.4 ± 1.2

0.43 (−0.01 to 0.87)

0.07

No. of top-quality embryos

1.0 ± 1.3

0.7 ± 0.9

0.28 (−0.04 to 0.59)

0.09

No. of D3 embryos transferred

1.0 ± 0.7

1.1 ± 0.8

−0.07 (−0.28 to 0.14)

0.52

No. of participants with supernumerary frozen embryos — n (%)

16 (11.9)

11 (7.1)

1.67 (0.80 to 3.48) a

0.16

  1. Categorical outcomes compared using two-sided chi-square or Fisher exact test. Continuous outcomes compared using two-sided Student’s t test of Mann–Whitney test. A two-sided P value < 0.05 was considered statistically significant. Results were not adjusted for multiplicity.
  2. IU international units, MII metaphase 2, 2PN two pronuclei, D3 day 3.
  3. aRelative risk (95% CI).