Fig. 1: Cryo-EM structure of the DNMT3A2-DNMT3L complex.
From: Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease
a Domain structure of DNMT3A2, with individual domains color coded and delimited by residue numbers. b Two opposite views of the density map for the DNMT3A2-DNMT3L complex, with individual subunits color coded. c Atomic structure of the DNMT3A2-DNMT3L complex, with individual domains color coded in the same fashion as in (b). Unless otherwise indicated, the 3A-1 subunit is used for structural analysis in this study. d Atomic structure of the 3A-1 subunit within the DNMT3A2-DNMT3L complex, with individual domains color coded. e Atomic structure of the 3A-2 subunit within the DNMT3A2-DNMT3L complex, with individual domains color coded. f Structure overlay of the two DNMT3L subunits in the DNMT3A2-DNMT3L complex with the DNMT3L molecule bound to a H3K4me0 peptide (PDB 2PVC). The N- and C-termini of each subunit in d-f are labeled with letter “N” and “C”, respectively.
