Fig. 3: Structural analysis of the autoinhibitory ADD-TRD interaction. | Nature Communications

Fig. 3: Structural analysis of the autoinhibitory ADD-TRD interaction.

From: Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease

Fig. 3: Structural analysis of the autoinhibitory ADD-TRD interaction.The alternative text for this image may have been generated using AI.

a Close-up view of the ADD-MTase interaction, with interacting residues shown in stick representation. b Mutational analysis the interaction between the DNMT3AMTase-DNMT3ML complex with the DNMT3A ADD domain by ITC binding assay. The Kd and standard deviation were derived from two independent measurements. One representative set of ITC binding data is shown. Source data are provided as a Source Data file.

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