Fig. 1: Asymmetric biomimetic transamination of α-keto phosphonates enabled by chiral pyridoxamine catalysts. | Nature Communications

Fig. 1: Asymmetric biomimetic transamination of α-keto phosphonates enabled by chiral pyridoxamine catalysts.

From: Asymmetric biomimetic transamination of α-keto phosphonates enabled by chiral pyridoxamines and synergistic solvent

Fig. 1: Asymmetric biomimetic transamination of α-keto phosphonates enabled by chiral pyridoxamine catalysts.

a Different approaches to N-unprotected chiral amines from ketone compounds and the transaminase-inspired chiral pyridoxamine catalysts. b Drug-like α-aminophosphonic acid compounds. c Representative approaches to N-protected chiral α-aminophosphonates. d This work: biomimetic transamination of α-keto phosphonates. PG protecting groups, PYR diphenylpyrimidine, TFE trifluoroethanol.

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