Fig. 5: Inhibition of DPP4 reduces migratory and Il1r2-high macrophages following influenza virus infection. | Nature Communications

Fig. 5: Inhibition of DPP4 reduces migratory and Il1r2-high macrophages following influenza virus infection.

From: Dipeptidylpeptidase 4 inhibition attenuates gestational pathologies via immune homeostasis restoration in the pulmonary-uterine axis

Fig. 5: Inhibition of DPP4 reduces migratory and Il1r2-high macrophages following influenza virus infection.

a Subclustering of macrophages in lungs identified six subtypes at 0.3 resolution. A color-coded uniform manifold approximation and projection (UMAP) plot is shown, with each subcluster defined on the right. b Violin plots of Il1r2 expression of each of macrophage cluster in lungs. c Violin plots of normalized expression of selected cluster-specific genes in lungs. Four genes are shown per cluster. d Proportion of each macrophage cluster in lungs infected with either saline or H1N1 alone, or treated with sitagliptin. e Group-separated UMAP plots with Immunoregulatory Mac cluster in green in lungs. f UMAP feature plots of Il1r2 expression of macrophage cluster in lungs infected with either saline or H1N1 alone, or treated with sitagliptin. g Subclustering of macrophages in deciduas identified four subtypes at 0.2 resolution. A color-coded uniform manifold approximation and projection (UMAP) plot is shown with each subcluster defined on the right. h Violin plots of Il1r2 expression of each of macrophage cluster in deciduas. i Violin plots of normalized expression of selected cluster-specific genes in deciduas. Four genes are shown per cluster. j Proportion of each macrophage cluster in deciduas infected with either saline or H1N1 alone, or treated with sitagliptin. k Group-separated UMAP plots, with Immunoregulatory Mac cluster in green in deciduas. l UMAP feature plots of Il1r2 expression of macrophage cluster in deciduas infected with either saline or H1N1 alone, or treated with sitagliptin. m, n UMAP feature plots of normalized expression of Retnlg, Cxcr2, Mmp9, Chil1, Steap4, and Nlrp12 of macrophage cluster in lungs (m) and deciduas (n). Source data are provided as a Source Data file.

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