Fig. 6: Blocking base excision repair impairs E2 response.
a Schematic of the RNA-seq experiment in this study. For each of the treatment groups, four biological repeats were conducted for T47D cells. b Dot plot showing log2 fold change of normalised transcript counts for 819 differentially expressed genes affected by E2 stimulation without the expression of A3B**-hUGI in T47D cells. c Heat maps showing normalised RNA-seq signals for 90 differentially expressed genes, the E2 response of which were modulated by A3B**-hUGI induction in T47D cells. Statistical results from DESeq2 are summarised in bars on the right. d Table showing MSigDB hallmark gene set enrichment analysis using 90 hit genes described in (c). Source data are provided as a Source Data file.
