Fig. 2: Multivariate associations between tract-based brain age gaps (BAGs; with age-bias correction) and behavioral assessments using sparse canonical correlation analysis (sCCA). | Nature Communications

Fig. 2: Multivariate associations between tract-based brain age gaps (BAGs; with age-bias correction) and behavioral assessments using sparse canonical correlation analysis (sCCA).

From: Deviation in development of dorsal association tracts during preadolescence links to concurrent and future cognitive performance and transdiagnostic psychopathology

Fig. 2: Multivariate associations between tract-based brain age gaps (BAGs; with age-bias correction) and behavioral assessments using sparse canonical correlation analysis (sCCA).

A Loadings of the brain features on the two sCCA modes. Color bar indicates sCCA loading. B Loadings of behavioral assessments on the two sCCA modes. Statistical significance was assessed using 1000 bootstrap resampling iterations, with loadings considered significant when the 95% confidence intervals excluded zero. Significant loadings are colored according to the behavioral/tract systems to which they belonged, with those specific to each mode highlighted with asterisks. C The Manhattan plot of the post-hoc associations between tract-based BAGs and all the behavioral measures. The dots above the gray dotted line indicate that the tract-based BAGs were significantly correlated with behavioral assessments (\({p}_{{FDR}} < 0.05\)). Tract-based BAGs with significant associations are labeled with colors. The top 10 tract-based BAGs that were significantly associated with cognition or psychopathology domains are highlighted with the tract names, respectively. The two-tailed p values with Benjamini-Hochberg false-discovery-rate (FDR) correction were provided in Source Data File. Abbreviations: AF Arcuate Fasciculus; FAT Frontal Aslant Tract; PAT Parietal Aslant Tract; SLF Superior Longitudinal Fasciculus; IFOF Inferior Fronto Occipital Fasciculus; ILF Inferior Longitudinal Fasciculus; UF Uncinate Fasciculus; MdLF Middle Longitudinal Fasciculus; C_FPH Cingulum Frontal Parahippocampal; C_FP Cingulum Frontal Parietal; C_PH Cingulum Parahippocampal; C_PHP Cingulum Parahippocampal Parietal; C_PO Cingulum Parolfactory; F Fornix; CST Corticospinal Tract; OR Optic Radiation; VOF Vertical Occipital Fasciculus; TR_A Thalamic Radiation Anterior; TR_P Thalamic Radiation Posterior; TR_S Thalamic Radiation Superior; CS_A Corticostriatal Tract Anterior; CS_P Corticostriatal Tract Posterior; CS_S Corticostriatal Tract Superior; CC Corpus Callosum; CC_Body CC Body; CC_Major CC Forceps Major; CC_Minor CC Forceps Minor; CC_Tap CC Tapetum; nihtbx: NIH Toolbox; MID Monetary Incentive Delay; SST_ssrt Stop Signal Reaction Time of Stop Signal Task; PQB Prodromal Questionnaire Brief Version; PGBI Parent General Behavior Inventory; CBCL Children Behavior Check List; ADHD Attention-deficit/hyperactivity Disorder; SCT Sluggish Cognitive Tempo; OCD Obsessive-compulsive Disorder; UPPS Urgency, Perseverance, Premeditation and Sensation-seeking; BISBAS: Behavioral Inhibition & Behavioral Activation Scales. See Supplementary Table 19 and 20 for more details of the behavioral measures. Source data are provided as a Source Data file.

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