Fig. 3: Results of tract-based functional decoding analysis.
A Workflow for evaluating meta-analytic functional decoding of two sparse canonical correlation analysis (sCCA) loading patterns of the tract-based brain age gaps (BAGs). Selected Neurosynth36 topic maps represented on cortical surface were visualized in the left top panel. For each topic, a tract-wise functional profile was calculated by averaging z-scored brain functional activation probability within the gray matter (GM) regions connected by each white matter (WM) tract. In the right panel, representative scatterplots of spatial correlations between tract-wise functional profiles and sCCA loading patterns are shown. B Functional decoding results for two sCCA loading patterns. Spearman correlation coefficients with two sCCA loading patterns are plotted on x and y axes, respectively. The significance of the results was used by one-sided spin-permutation test, with Benjamini-Hochberg false-discovery-rate (FDR) correction applied. The significantly correlated topics are highlighted and labeled. C Proportions of the functional networks connected by the WM tracts significant in the two sCCA modes. Pie plots demonstrate the percentages of tract-connected cortical voxels located in the seven resting-state cortical networks (defined by Yeo et al. 37) for the two sCCA modes. Abbreviations: SMN sensorimotor network; DAN dorsal attention network; VAN ventral attention network; FP frontoparietal network; DMN default mode network; FDR false discovery rate; PTSD Posttraumatic Stress Disorder; ADHD Attention-deficit/hyperactivity Disorder; AF Arcuate Fasciculus; FAT Frontal Aslant Tract; PAT Parietal Aslant Tract; SLF Superior Longitudinal Fasciculus; IFOF Inferior Fronto Occipital Fasciculus; ILF Inferior Longitudinal Fasciculus; UF Uncinate Fasciculus; MdLF Middle Longitudinal Fasciculus; C_FPH Cingulum Frontal Parahippocampal; C_FP Cingulum Frontal Parietal; C_PH Cingulum Parahippocampal; C_PHP Cingulum Parahippocampal Parietal; C_PO Cingulum Parolfactory; F Fornix; CST Corticospinal Tract; OR Optic Radiation; VOF Vertical Occipital Fasciculus; TR_A Thalamic Radiation Anterior; TR_P Thalamic Radiation Posterior; TR_S Thalamic Radiation Superior; CS_A Corticostriatal Tract Anterior; CS_P Corticostriatal Tract Posterior; CS_S Corticostriatal Tract Superior; CC Corpus Callosum; CC_Body CC Body; CC_Major CC Forceps Major; CC_Minor CC Forceps Minor; CC_Tap CC Tapetum. Source data are provided as a Source Data file.
