Fig. 7: Distinct lipid–protein interactions and regulatory mechanisms of CDL and PG in VsSemiSWEET.
From: Diverse regulation of functional dimerization of a sugar transporter by different interfacial lipids
a Molecular topology comparison: PG (single phosphatidylglycerol headgroup with two acyl chains) versus CDL (dimeric phosphatidylglycerol containing four acyl chains). b Regulatory mechanisms: In the absence of lipids, VsSemiSWEET forms unstable dimers due to repulsion between interfacial basic residues. PG acyl tails insert into the interfacial cavity of VsSemiSWEET, disrupting interprotomer interactions and inhibiting the functional transition cycle. In contrast, the acyl tails of CDL interact with TM2, stabilizing the dimeric structure and facilitating functional transitions.
