Fig. 2: Optimizing ligands for next-generation stereospecific glycosyl cross-coupling. | Nature Communications

Fig. 2: Optimizing ligands for next-generation stereospecific glycosyl cross-coupling.

From: Ligand-enabled next-generation glycosyl Stille cross-coupling for the stereospecific synthesis of sterically hindered aryl C-glycosides

Fig. 2: Optimizing ligands for next-generation stereospecific glycosyl cross-coupling.

Standard reaction conditions: 14a (0.05 mmol), 16 (0.075 mmol), Pd2(dba)3 (2.5 mol%), ligand (10.0 mol%), CuCl (300 mol%), KF (200 mol%), 1,4-dioxane (1.50 mL), 110 °C, 48 h, N2, The yields and stereochemical outcome were determined by 1H NMR analysis of crude reaction mixtures. a isolated yield.

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