Table 1 Identification of causal circulating proteins for forearm fractures using an MR pipeline
From: Identification of ephrin-A1–EphA2 signalling as a potential target for fracture prevention
Gene | Protein | Beta | SE | P | Colocalization | Previous MR evidence for fractures in humans | Known to associate with BMD in humans | Approved osteoporosis drug |
|---|---|---|---|---|---|---|---|---|
RSPO3 | R-spondin 3 | − 0.58 | 0.04 | 6.5E-43 | Yes | Yes | Yes | – |
DKK1 | Dickkopf-related protein 1 | 0.44 | 0.05 | 3.4E-20 | Yes | – | Yes | – |
FAM3C | FAM3C | − 0.60 | 0.07 | 1.1E-15 | – | – | – | – |
SOST | Sclerostin | 0.76 | 0.11 | 2.4E-12 | Yes | Yes | Yes | Yes |
TNFRSF11B | Tumour necrosis factor receptor superfamily member 11B | − 0.19 | 0.03 | 1.2E-09 | – | – | Yes | Yes |
MEPE | Matrix extracellular phosphoglycoprotein | − 0.26 | 0.05 | 5.4E-08 | Yes | – | Yes | – |
CCND2 | Cyclin D2 | 0.66 | 0.13 | 2.4E-07 | Yes | – | – | – |
EFNA1 | Ephrin-A1 | − 0.11 | 0.02 | 4.9E-06 | Yes | – | – | – |
TIMP2 | Metalloproteinase inhibitor 2 | 0.34 | 0.08 | 1.0E-05 | Yes | – | Yes | – |
