Fig. 8: ECSASB9 E3 ubiquitin ligase governs male fertility via microtubule destabilization. | Nature Communications

Fig. 8: ECSASB9 E3 ubiquitin ligase governs male fertility via microtubule destabilization.

From: A testis-specific E3 ubiquitin ligase complex governs spermiogenesis and male fertility

Fig. 8: ECSASB9 E3 ubiquitin ligase governs male fertility via microtubule destabilization.The alternative text for this image may have been generated using AI.

Pathogenic ASB9 variants in humans and genetic ablation of the ECSASB9 complex in mice drive OAT and impair fertility. Mechanistically, ECSASB9 targets TUBB4A, catalyzing K48-linked polyubiquitination at lysine 379 to trigger proteasomal degradation. This ubiquitin-dependent regulation ensures precise manchette microtubule dynamics and sperm head shaping during spermiogenesis.

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