Fig. 2: Structural information on NadA in situ (native NadA exposed on the OMV surface). | Nature Communications

Fig. 2: Structural information on NadA in situ (native NadA exposed on the OMV surface).

From: Structural dynamics and immunogenicity of the recombinant and outer membrane vesicle-embedded Meningococcal antigen NadA

Fig. 2: Structural information on NadA in situ (native NadA exposed on the OMV surface).The alternative text for this image may have been generated using AI.

A Representative raw of Negative Staining TEM image of meningococcal bare OMVs (OMVs without NadA – left panel) and OMVs carrying on the surface several NadA copies (indicated with white arrows – right panel). Scale bar is 60 nm. B Difference in HDX between rNadA and OMV-embedded NadA. Positive values indicate that rNadA undergoes faster HDX than OMV-embedded NadA, hence a rigidification of OMV-embedded NadA compared to rNadA. The dashed black line indicates 0.61 Da (99% CI) as a threshold for statistical significance. On the x-axes, peptides are listed according to the peptide center residue (peptides 24–39, 40–58, 40–59, and 327–340 are not plotted as they manifest bimodal HDX behavior; their isotopic envelopes are represented in Fig. 3b). Source data are provided as a Source Data file.

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