Fig. 4: Immune response elicited by rNadA and OMV-embedded NadA. | Nature Communications

Fig. 4: Immune response elicited by rNadA and OMV-embedded NadA.

From: Structural dynamics and immunogenicity of the recombinant and outer membrane vesicle-embedded Meningococcal antigen NadA

Fig. 4: Immune response elicited by rNadA and OMV-embedded NadA.The alternative text for this image may have been generated using AI.

A NadA-specific IgG titers of sera from mice immunized with NadA-OMVs (5 µg) or with rNadA (20 µg) as measured by ELISA. Each dot represents an individual mouse serum (n = 5), while the error bars indicate the mean value ± SD within each immunization group. IgG α-NadA antibody titers elicited measured by ELISA, where each dot represents an individual mouse serum while lines indicate the median value within each immunization group. B Serum bactericidal antibody (SBA) titers against BZ83 meningococcal strain. Dots represent SBA titers of individual mouse sera (n = 5) against the defined strain, while the error bars indicate the mean value ± SD. Statistical analysis was performed using Kruskal-Wallis multiple comparisons test (ns: not significant; *p < 0.05 (0.0444); ***p < 0,0001 (0.0007)). Source data are provided as a Source Data file.

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