Table 2 Antitumor activity evaluation

From: Discovery and engineering of bacterial P450s for C-14 hydroxylation in ent-kaurane diterpenoids

Cell line

IC50 (μM)

1

2

3

4

9

26

27

cis-platin

HCT116

>100**

>100

>100

>100

5.5 ± 1.6

49.4 ± 4.8

1.4 ± 0.7

24.2 ± 3.8

LLC

>100

30.4 ± 1.3

78.6 ± 7.2

29.0 ± 7.2

11.0 ± 1.2

56.4 ± 8.1

2.1 ± 0.5

15.7 ± 4.1

  1. Cytotoxicity assays against human colorectal tumor (HCT116) and Lewis lung carcinoma (LLC) cell lines identified 27 as the most potent derivative. Cis-platin was used as a reference drug for comparison. Data are expressed as mean ± standard deviation (SD) from three biological replicates. Compounds marked with two asterisks (**) indicate that precipitation occurred during bioactivity tests. Source data are provided as a Source Data file.
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