Fig. 4: Structural and morphological characterization of WDR5 oligomerization.
From: Catalytic Proximal Protein Oligomerization as an Anti-Tumor Strategy Targeting WDR5
a Crystal structure of monomeric WDR5 (light blue; PDB ID: 2H68) showing the positions of cysteine residues. b Predicted dimeric WDR5 structure (pink and teal) generated by AlphaFold, with a spatial separation of 7.6 Å between the two cys248 residues. c Representative 2D classification images illustrating distinct tag-free WDR5 aggregation states induced by WZ‑1. d Schematic diagram of the CaPPO process, showing the formation of dimeric and oligomeric WDR5.
