Fig. 1: Wzm-WztMabs structures in LMNG.
From: Structural basis of lipid-linked galactan export by the mycobacterial ABC transporter Wzm-Wzt
a Cryo-EM maps of Wzm-WztMabs in LMNG micelle. b Models of apo/ADP-bound and ATP-bound Wzm-WztMabs with labelled structural elements are shown as cartoon. Slices at three levels indicated by green, pink and orange dotted lines represent views from the periplasm on aromatic belts within the TMD. Cavities calculated with the 3 V tool are shown in red. c LMNG binding site (orange sticks) with corresponding cryo-EM densities (shown as grey transparent surface at 5σ) between two adjacent TMDs of Wzm-WztMabs. Residues surrounding LMNG are shown as pink sticks. d Topology of Wzm-WztMabs TMD. The NBD is shown schematically. IF – interface helix, CH – coupling helix, PG – periplasmic gate helix.
