Fig. 4: Highest expression of IL-17RA is on Paneth progenitors. | Nature Communications

Fig. 4: Highest expression of IL-17RA is on Paneth progenitors.

From: IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation

Fig. 4: Highest expression of IL-17RA is on Paneth progenitors.The alternative text for this image may have been generated using AI.

A The expression pattern of Il17ra and Il17rc genes on Paneth 1, Paneth 2, Paneth progenitors and intestinal stem cells (PMID: 29144463). B Scatter plot expression of Il17ra and Lyz1 on mature Paneth cells, Paneth progenitors, and intestinal stem cells (PMID: 29144463). C Scatter plot expression of Il17rc and Lyz1 on mature Paneth cells, Paneth progenitors, and intestinal stem cells (PMID: 29144463). D Representative flow cytometry plot from PanethYFP mice depicting high and low YFP expression. E RT-qPCR analysis of Lyz1, Il17rc, Il17ra, and Olfm4 between low YFP and high YFP populations of Paneth cells from naïve PanethYFP mice. Mice were 7.6, 9.9, and 3.3 weeks old. N = 6. F Single-cell RNA sequencing heat map data depicting expression of IL-17 receptor family genes from non-irradiated and irradiated Paneth cells (PMID: 29887318). N = number of biologically independent mice. Figure 4D, E are generated from 3 independent experiments. (Wilcox paired test, Two-tailed).

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