Fig. 9: Application of the discovery of potent inhibitors of FLT3. | Nature Communications

Fig. 9: Application of the discovery of potent inhibitors of FLT3.

From: A meta learning and task adaptive approach for drug target affinity prediction

Fig. 9: Application of the discovery of potent inhibitors of FLT3.The alternative text for this image may have been generated using AI.

a Visualization of the FLT3 structure used in AutoDock docking (PDB ID:6JQR). b AdaMBind identified several potential inhibitors for the FLT3 target. The 3D binding poses of 6 compounds with the FLT3 protein were generated using AutoDock. Experimental Validation of Predicted Relationships. c 2D diagram of the interaction between FLT3 and Staurosporine simulated by AutoDock. d Concentration-activity curves of Quizartinib (positive control) and Staurosporine in FLT3 kinase ADP-Glo assays for WT-type (left) and ITD-type (right). Mean ± SEM of three independent experiments is shown (n = 3). Source data are provided as a Source Data file.

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