Fig. 5: Islet secretion traits by sex.
From: Heterogeneous endocrine cell composition defines human islet functional phenotypes
Violin plots comparing (a) insulin and (b) glucagon secretion traits between female (pink, n = 115) and male (blue, n = 184) donors. The solid line in each violin plot depicts the median, and the dotted lines represent the 1st and 3rd quartiles. P value is based on the two-sided test while controlling for the seven covariates (age, sex, BMI, HbA1c, islet isolation center, pre-shipment culture time, and islet transit time) and adjusting for multiple comparisons using the false discovery rate correction. Comparisons where the unadjusted p value (punadj) was significant are noted in italics: punadj = 0.035 for KCl-mediated stimulation index for glucagon secretion traits. P values, test statistics, and effect sizes with 95% confidence intervals are reported in Source Data Fig. 5. Abbreviations: cAMP cyclic adenosine monophosphate; KCl potassium chloride.
