Fig. 7: Islet composition and hormone content are associated with multiple islet secretory traits.

a, b Heatmaps depicting regression coefficients of each islet composition variable (n = 299), hormone content variable (n = 299), morphologic variable for islets that underwent perifusion (n = 186), or morphologic variable representative of all islets in the preparation (n = 195) after being incorporated into multivariable regression models controlling for age, sex, BMI, HbA1c, islet isolation center, reported race or ethnicity, pre-shipment culture time, and islet transit time for each (a) insulin or (b) glucagon secretion trait. c Heatmaps depicting regression coefficients of each islet composition variable after being incorporated into multivariable regression models for total insulin or glucagon content after adjusting for the eight covariates (n = 299). Shading represents different regression coefficients. P values, based on the two-sided t-test, are reported in Source Data Fig. 7. Adjusted p-values, using the false discovery rate correction, are indicated where *p < 0.05, **p < 0.01, and ***p < 0.001. Comparisons where the unadjusted p-value was significant are noted in italics. Abbreviations: cAMP – cyclic adenosine monophosphate; KCl – potassium chloride.