Fig. 7: Fate of T cells and dendritic cells during tolerance and following graft destruction. | Nature Communications

Fig. 7: Fate of T cells and dendritic cells during tolerance and following graft destruction.

From: Antigen-specific immunotherapy with a CD4+ T cell neoepitope restrains CD8+ T cell differentiation in murine pancreatic islet grafts

Fig. 7: Fate of T cells and dendritic cells during tolerance and following graft destruction.The alternative text for this image may have been generated using AI.

a Experimental design to examine 2.5HIP NP tolerized grafts at d15 post-transplant and upon graft failure. b Proportion (%) and absolute numbers (#) of 2.5HIPCD4 T cells in kLN and grafts. c Proportion of TCF1hi staining of 2.5HIPCD4 T cells from kLN and grafts. d Proportion (%) and absolute numbers (#) of IGRPCD8 T cells in kLN and grafts. e Proportion of TCF1hi staining of IGRPCD8 T cells from kLN and grafts. f Proportion (%) FOXP3+ of 2.5HIPCD4 T cells in kLN and grafts. f Proportion (%) CD40hi of cDC1 and cDC2 dendritic cells in grafts. In b-g data are depicted as the mean ± s.e.m. with p-values obtained from a two-sided unpaired Student’s t-test. In (b–g), n = 3 mice for both groups. Data are compiled from 4 independent experiments.

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