Fig. 3: CMV-associated signatures at the gene expression and plasma protein abundance. | Nature Communications

Fig. 3: CMV-associated signatures at the gene expression and plasma protein abundance.

From: Molecular signatures and causal factors underlying latent cytomegalovirus infection among people living with HIV (PLHIV)

Fig. 3: CMV-associated signatures at the gene expression and plasma protein abundance.The alternative text for this image may have been generated using AI.

A Gene expression signatures (DEG) which were significantly associated with CMV seropositivity. The dots present DEGs in discovery cohorts (FDR < 0.05). The purple color presents DEGs that were validated in the validation cohort (P < 0.05). We labeled some DEGs which were also cis-eQTM significant genes. B The number of sig. pathways for GO analysis with validated DEGs. C Pathway network of validated DEGs. D Pathway cluster of validated DEGs, which were upregulated in CMV-seropositive PLHIV. E Plasma protein signatures (DEP), which were significantly associated with CMV seropositivity. The dots present DEPs in discovery cohorts (FDR < 0.05). The purple color presents DEPs that were validated in the validation cohort (P < 0.05). We labeled 8 DEPs, which were also validated DEGs. F The level of FCRL6 across omics layers (methylation, gene expression, protein levels; n = 1512 for discovery and 317 for validation cohort). In boxplots, center lines represent medians, boxes indicate 25th and 75th percentiles, and whiskers expand to 1.5× the interquartile range. Statistical tests were conducted using linear models adjusted for confounding effects, with two-sided testing and multiple-test adjustments by FDR. G Suggested scheme of FCRL6 regulation in CMV-seropositive PLHIV. Created in BioRender. Jiang, X. (2026) https://BioRender.com/6fxflef.

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