Fig. 6: Membrane binding mode of the vault in comparison with canonical SPFH family members. | Nature Communications

Fig. 6: Membrane binding mode of the vault in comparison with canonical SPFH family members.

From: The vault associates with membranes in situ

Fig. 6: Membrane binding mode of the vault in comparison with canonical SPFH family members.The alternative text for this image may have been generated using AI.

a Representation of the MVP monomer domain architecture (top) and exemplary localization within the vault complex 78-mer (bottom). Model: PDB 4V6030. b Domain architecture of SPFH proteins. Berry: MVP domains, orange: SPFH domains, teal: transmembrane or membrane-associated helical domains, dashed line: approximate region of membrane association. c Side-by-side comparison of structural models and domain arrangements of protein cages (PDB 4V6030, Flotillin 9BQ240, Erlin 9O9U7, Stomatin 9OH950, Prohibitin 9O6S51 QmcA 8Z5G38, HflC/K 7WI337). Orange: SPFH domains, teal: transmembrane or membrane associated helices, berry: MVP domains. Dashed line: Approximate membrane association region. The domains C-terminal of the SPFH domain in the vault PDB model were cropped to illustrate vault’s membrane binding mode (second from left).

Back to article page