Table 2 Identified TBL1XR1 interaction partners in pancreatic β-cells

From: TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network

Protein name

Protein description

Unique peptide count

Ratio TBL1XR1/Flag

p-value

IF4E

Eukaryotic translation initiation factor 4E

2

28,1

<0.0001

TBL1XR1

F-box-like/WD repeat-containing protein

12

11,4

<0.0001

PAX6

Paired box protein 6

3

9,7

0.0088

HDAC3

Histone deacetylase 3

14

9,6

0.0004

MEOX2

Homeobox protein MOX-2

3

6,8

0.0045

NCOR2

Nuclear receptor corepressor 2

44

5,2

0.0002

NCOR1

Nuclear receptor corepressor 1

46

5,1

0.0016

DLDH

Dihydrolipoyl dehydrogenase

9

4,8

0.0022

GPS2

G protein pathway suppressor 2

7

4,7

0.0038

OSB5

Proteasome subunit beta type-5

2

3,3

0.0105

CUX1

Homeobox protein cut-like 1

3

3,2

0.0037

UACA

Uveal autoantigen with coiled-coil domains and ankyrin repeats

35

3,1

0.0004

RMI1

RecQ-mediated genome instability protein 1

3

2,9

0.0104

RBBP4

Histone-binding protein RBBP4

2

2,9

0.0072

SMC2

Structural maintenance of chromosomes protein 2

2

2,8

0.119

NDUAD

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

2

2,7

0.1734

TFE3

Transcription factor E3

4

2,5

0.0361

CKAP4

Cytoskeleton-associated protein 4

9

2,4

0.00608

KDM1A

Lysine-specific histone demethylase 1A

6

2,4

0.0248

SPT16

FACT complex subunit SPT16

3

2,4

0.121

  1. Top 20 nuclear TBL1XR1 interaction partners. After TBL1XR1 enrichment with an endogenous immunoprecipitation, interaction partners were identified using mass spectrometry. The ratio TBL1XR1/Flag shows the enrichment of the respective protein in the TBL1XR1 pulldown relative to the enrichment in the pulldown using Flag antibody. Statistical analysis was performed using a two-sided student’s t test. n = 4 wells per condition.
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