Fig. 2: Intersection between METR-eQTLs and eQTLs from different studies. | Nature Communications

Fig. 2: Intersection between METR-eQTLs and eQTLs from different studies.

From: Paired DNA and RNA sequencing uncovers common and rare variation regulating human retinal gene expression

Fig. 2: Intersection between METR-eQTLs and eQTLs from different studies.The alternative text for this image may have been generated using AI.

a Overlap between METR-eQTLs (left) and METR-eGenes (right) identified in the neurosensory retina (NSR) and the retinal pigment epithelium (RPE). b Intersection between eGenes identified in the neurosensory retina (METR-NSR), EyeGex15 and Strunz et al.16 retina eQTL study. For eGenes which were present in METR-NSR and at least one other study, we compared the top eQTL for each eGene to identify 1) eQTLs which were replicated in an additional study/studies; 2) eGenes where the top eQTL from each study was in high LD with each other (r2 > 0.8) and 3) eGenes where the top NSR hit was novel. The LD score was unavailable for a subset of eQTLs. c Comparison between METR-eQTLs and GTEX eQTLs indicates the number of NSR-specific, RPE-specific, NSR & RPE-specific and non-eye-specific eQTLs (left) and eGenes (right) from both tissues in our study.

Back to article page