Abstract
Dalesconols A and B, featuring unique and highly congested polycyclic carbon frameworks and notable biological activities, have attracted sustained attention. However, their structural complexity constitutes a significant challenge for total synthesis. Herein, we present the asymmetric total syntheses of (+)-dalesconols A and B via a remote chirality transfer strategy. Central to this approach is the implementation of our palladium/norbornene-catalyzed trifunctionalization method, which enables one-step construction of the chiral polycyclic core skeleton via a triple relay of point-to-axial, axial-to-axial, and axial-to-point chirality transfer. Combined with intramolecular Michael addition, C−H oxidation/retro-Michael elimination, and global demethylation, this triple-relayed remote chirality transfer strategy allows concise and modular access to (+)-dalesconols A and B.
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We acknowledge financial support from the National Natural Science Foundation of China (22371227, U24A20486, 22171225), Key Research and Development Program of Shaanxi (2024SF2-GJHX-66), and Shaanxi Fundamental Science Research Project for Chemistry & Biology (22JHZ001, 23JHQ010).
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Guo, Y., Liu, J., Gao, W. et al. Total syntheses of (+)-dalesconols A and B enabled by triple-relayed remote chirality transfer. Nat Commun (2026). https://doi.org/10.1038/s41467-026-73353-0
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DOI: https://doi.org/10.1038/s41467-026-73353-0
