Fig. 1: Patient 1: Clinical responses and patient-reported outcome in refractory IgM-paraproteinemic autoimmune neuropathy treated with teclistamab.
From: Therapeutic effect of T-cell engager in two patients with autoimmune neuropathy
A Upper Panel: Left: Overview of disease course until 9 months (287 days) post-treatment follow up, prior treatment approaches, ultrasound pattern sum score (UPSS; both sides; range 0 [normal] to 44 [most severe]), and nerve conduction velocity recordings [right median nerve; normal value: > 50 m/s]. Green area: Results after teclistamab treatment. Right: Electroneurographic recordings of right median and left peroneal nerve prior treatment with teclistamab (baseline; black) and 9 months after first teclistamab dose (red) showing increased amplitudes and reduced distal motor latency (DML). Lower Panel: Left: Inflammatory Neuropathy Cause and Treatment disability score (INCAT; range 0 [normal] to 10 [most severe]) illustrating improvement of neuropathy symptoms. Nerve sonography: Median (arrow-head) and tibial nerve (arrow) sonography at baseline and month 9 showing a reduction of nerve swelling. Right: Distal compound muscle action potential (CMAP) amplitude of the right and DML recordings of the left tibial nerve showing a profound improvement. Green area: Normal values. B Patient-reported Outcome: Inflammatory Rasch-built Overall Disability Scale (I-RODS) is a patient-reported outcome scale specifically designed to assess activity and social participation limitations in patients with inflammatory polyneuropathies (range 0 [most severe] to 48 [normal]). painDETECT score: painDETECT is a patient-completed screening questionnaire designed to identify neuropathic pain components in individuals with chronic pain conditions (range 0 [no pain] to 35 [most severe]). The Short Form 36 Health Survey (SF-36): SF-36 at baseline and month 9. The SF-36 is a widely used, patient-reported questionnaire designed to measure health-related quality of life across a broad range of diseases and populations. Abbreviations: St: high-dose steroids, IVIG: intravenous immunoglobulins, Px: plasma exchange, CIDP: Chronic inflammatory demyelinating polyneuropathy, BA: brachial artery, CSA: cross-sectional area CMAP: compound muscle action potential, DML: distal motor latency. Source data are provided as a Source Data file.
