Fig. 6: Radiation-specificity of senotherapeutics in dermal fibroblasts.
From: Space radiation induces distinct senescent phenotypes: Implications for space travel
Quantification of C12FDG senescence assay on fibroblasts exposed to 0.5 Gy (a-c) Gamma, (d-f) Silicon, (g-i) Hydrogen, (j-l) Iron radiation treated for 48 h with (a,d, g, j) 20uM fisetin (b, e, h, k) the combination of 125 nM dasatinib and 25uM quercetin (DQ) or (c, f, i, l) 10uM Navitoclax. Values are the number of all stained nuclei (total cells) or live cells that are C12FDG+ (C12+) normalized to the respective DMSO control treated cells ± S.E.M. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 (n = 3).
