Fig. 3: Increased neurotrophic factors in frontal cortex and in circulating blood of normal aging- and senescence accelerated mice. | npj Aging

Fig. 3: Increased neurotrophic factors in frontal cortex and in circulating blood of normal aging- and senescence accelerated mice.

From: Stimulation at the frontal cortex influences the exercise activity and skeletal muscle status in senescence-accelerating mice

Fig. 3

a Gene expression for Bdnf and Ngf. b Western blotting for BDNF, NGF, TrkB and TrkA. c Protein expression of BDNF, NGF, TrkA and TrkB. d Immunohistochemistry for BDNF and NGF. NeuN is a marker for nucleus of neuron. Scale bar, 50 μm. e Gene expression for Iba1, Cd68 and Gfap. f Serum BDNF levels. b-actin, beta actin; BDNF, brain-derived neurotrophic factor; Cd68, cluster of differentiation 68; Gfap, glial fibrillary acidic protein; Iba1, ionized calcium-binding adapter molecule 1, NeuN, neuronal nuclei; NGF, nerve growth factor; SP8-Ap, senescence-accelerated prone mice 8 received acupuncture stimulation; SP8-C, senescence-accelerated prone mice 8 without acupuncture stimulation; SR1, senescence-accelerated resistant mice 1 without acupuncture stimulation, Trk, tyrosine protein kinase.

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