Fig. 4: Local inflammation in gastrocnemius muscle of normal aging- and senescence accelerated mice.

a Hematoxylin and eosin staining of skeletal muscle. Scale bar, 50 μm. b Major and width of skeletal muscle cells. c Gene expression of Itgam, Adgre1 and Cd80. d Immunohistochemistry for CD11b. e Immunohistochemistry for F4/80. Scale bar, 50 μm. Adgre1, epidermal growth factor-like module-containing mucin-like hormone receptor-like 1 (EMR1, F8/40); Cd, cluster of differentiation; Itgam, integrin-α M (CD11b); SP8-Ap, senescence-accelerated prone mice 8 received acupuncture stimulation; SP8-C, senescence-accelerated prone mice 8 without acupuncture stimulation; SR1, senescence-accelerated resistant mice 1 without acupuncture stimulation.