Fig. 2: Associations of omega-6 intake, omega-3 intake, and the ratio of polyunsaturated:saturated fatty acids (P:S) with epigenetic aging biomarkers.
Effect estimates (95% confidence intervals (CIs)) are shown for a log2 increase, or doubling, of omega-6 and omega-3 intake and for a one-unit increase in the P:S ratio, which approximates the interquartile range. Units are in years for the Horvath1, Horvath2, Hannum, Lin, Zhang, Vidal-Bralo, PhenoAge, and GrimAge2 clocks; kilobases for DNAmTL, and standard deviations for epiTOC and DunedinPoAm. Results are from weighted generalized linear regression models adjusted for age, age2, sex, race and ethnicity, BMI, education level, occupation, poverty to income ratio, smoking status, alcohol intake, physical activity, and total energy intake. Significant associations (p < 0.05) are plotted in red.
