Fig. 1: Aanalysis of liver function, cholesterol, levels of oxysterol and MMSE in AD and MCI patients. | npj Aging

Fig. 1: Aanalysis of liver function, cholesterol, levels of oxysterol and MMSE in AD and MCI patients.

From: 27-Hydroxycholesterol triggers microglial senescence subsequent to iron over-loading contributes to brain aging, suppressed by Deferoxamine

Fig. 1: Aanalysis of liver function, cholesterol, levels of oxysterol and MMSE in AD and MCI patients.

A, B Concentrations (U/L) of glutamic oxalacetic transaminase (AST) and glutamic pyruvic transaminase (ALT) in each group. C The ratio of AST to ALT in each group. D Concentrations (mmol/L) of cholesterol in each group. E, F The 27-OHC and 24S-OHC concentration (ng/ml) was obtained by established enzyme-linked immunosorbent assay (ELISA). G The ratio of 27-OHC to 24S-OHC in each group (*p <0.05, **p <0.01, ***p <0.001vs. Control). H Correlations between levels of ST/LT and MMSE score (r = −0.56, *p = 0.007). I Correlations between levels of Cholesterol and MMSE score (r = -0.61, p = 0.007). J Correlations between levels of 27-OH and MMSE score r = -049, p = 0.045). K Correlations between levels of 24S-OHC and MMSE score (for AD group: r = 0.57, p = 0.015).

Back to article page