Fig. 4: Associations of metabolomic signatures with corresponding dietary pattern scores and biological aging.
From: EAT-Lancet and plant-based diets, plasma metabolomic signatures, and biological aging
A–D Correlations between dietary pattern scores and the corresponding metabolomic signatures; E–H associations between per SD increment in dietary metabolomic signatures and biological aging from different models. Model 1 were adjusted for age and sex; model 2 were expanded to adjust for race, Townsend index, BMI, smoking status, healthy drinking, physical activity, healthy sleep score, cardiovascular disease, cancer, diabetes, high cholesterol, hypertension, respiratory disease, and medication for cholesterol-lowering, anti-hypertensive, or anti-diabetes; model 3, the adjustment of related dietary pattern score was further conducted to examine association independence. PDI plant-based diet index; HPDI healthy plant-based diet index; UPDI unhealthy plant-based diet index; SD standard deviation; BMI body mass index; KDM-BA Klemera-Doubal biological age; PhenoAge phenotypic age.
