Table 2 Associations between time since menopause (TSM), metabolomic signature (at baseline), and CVD risk

From: Integrating menopause duration and plasma metabolomics enhances cardiovascular risk stratification in aging women

 

TSM per 1 incrementa

Metabolomic signature per 1-SD increment

HR (95% CI)

P

HR (95% CI)

P

CVD

 Model 1

1.17 (1.15, 1.20)

<0.001

1.25 (1.22, 1.28)

<0.001

 Model 2

1.15 (1.13, 1.18)

<0.001

1.24 (1.21, 1.27)

<0.001

 Model 3

1.14 (1.12, 1.17)

<0.001

1.19 (1.17, 1.22)

<0.001

 Model 4

1.14 (1.11, 1.16)

<0.001

1.18 (1.15, 1.21)

<0.001

MI

 Model 1

1.24 (1.17, 1.31)

<0.001

1.30 (1.23, 1.37)

<0.001

 Model 2

1.21 (1.15, 1.28)

<0.001

1.28 (1.21, 1.35)

<0.001

 Model 3

1.19 (1.13, 1.26)

<0.001

1.23 (1.17, 1.30)

<0.001

 Model 4

1.18 (1.12, 1.25)

<0.001

1.21 (1.15, 1.28)

<0.001

AF

 Model 1

1.17 (1.13, 1.21)

<0.001

1.22 (1.18, 1.26)

<0.001

 Model 2

1.16 (1.12, 1.20)

<0.001

1.21 (1.17, 1.25)

<0.001

 Model 3

1.15 (1.12, 1.20)

<0.001

1.17 (1.13, 1.21)

<0.001

 Model 4

1.15 (1.11, 1.19)

<0.001

1.15 (1.11, 1.20)

<0.001

HF

 Model 1

1.24 (1.18, 1.31)

<0.001

1.43 (1.36, 1.50)

<0.001

 Model 2

1.21 (1.15, 1.27)

<0.001

1.40 (1.33, 1.47)

<0.001

 Model 3

1.19 (1.13, 1.25)

<0.001

1.31 (1.25, 1.38)

<0.001

 Model 4

1.18 (1.12, 1.24)

<0.001

1.30 (1.23, 1.36)

<0.001

IHD

 Model 1

1.21 (1.17, 1.26)

<0.001

1.30 (1.25, 1.34)

<0.001

 Model 2

1.19 (1.14, 1.23)

<0.001

1.28 (1.23, 1.33)

<0.001

 Model 3

1.17 (1.13, 1.21)

<0.001

1.23 (1.18, 1.27)

<0.001

 Model 4

1.16 (1.12, 1.21)

<0.001

1.21 (1.17, 1.26)

<0.001

Stroke

 Model 1

1.16 (1.10, 1.23)

<0.001

1.23 (1.16, 1.30)

<0.001

 Model 2

1.14 (1.08, 1.21)

<0.001

1.21 (1.14, 1.28)

<0.001

 Model 3

1.13 (1.07, 1.19)

<0.001

1.19 (1.12, 1.26)

<0.001

 Model 4

1.12 (1.06, 1.19)

<0.001

1.18 (1.11, 1.25)

<0.001

  1. Model 1 adjusted for age. Model 2 further adjusted for ethnicity, education, income and Townsend index of deprivation based on model 1. Model 3 further adjusted for smoking status, alcohol intake, sleep status, diet status, BMI, and family history of CVD based on model 2. Model 4 further adjusted for both time since menopause and metabolomic signature to assess their independent associations.
  2. CI confidence interval, HR hazard ratio, CVD cardiovascular diseases, MI myocardial infarction, AF atrial fibrillation, HF heart failure, IHD ischemic heart disease.
  3. aOne unit representing a 5-year interval.
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