Table 4 Association of BA slope with cancer incidence after 8-year follow-up
From: Epigenetic aging and cancer incidence in a German cohort of older adults
Predictors | Cancer free (N = 625) | Incident cancer (N = 159) | Model 1 | Model 2 | ||
|---|---|---|---|---|---|---|
Median (IQR) | Median (IQR) | HR per SD (95%CI) | p-value | HR per SD (95%CI) | p-value | |
PCHorvath slope | 0.52 (0.38 - 0.68) | 0.59 (0.45 - 0.74) | 1.29 (1.11 - 1.49) | 7.42E-4 | 1.37 (1.16 - 1.61) | 1.86E-4 |
PCSkinBloodClock slope | 0.46 (0.27 - 0.65) | 0.53 (0.36 - 0.69) | 1.26 (1.07 - 1.48) | 0.005 | 1.33 (1.12 - 1.59) | 0.001 |
PCHannum slope | 0.58 (0.35 - 0.78) | 0.65 (0.48 - 0.85) | 1.25 (1.06 - 1.48) | 0.008 | 1.34 (1.11 - 1.61) | 0.002 |
PCPhenoAge slope | 0.56 (0.13 - 0.91) | 0.63 (0.30 - 0.95) | 1.26 (1.06 - 1.51) | 0.010 | 1.34 (1.11 - 1.62) | 0.002 |
PCGrimAge slope | 0.61 (0.42 - 0.78) | 0.64 (0.48 - 0.78) | 1.17 (0.99 - 1.38) | 0.072 | 1.24 (1.04 - 1.48) | 0.018 |
