Fig. 1: Segatella isolates from a single FijiCOMP participant’s gut microbiome cluster into six clades.

A A cluster map of the genes within the 63 genomes isolated from the Fiji_W2.48.ST FijiCOMP gut microbiome, the genome of S. copri DSM18205 downloaded from RefSeq, and the 94 isolate genomes from previous studies. Core genes are defined as those genes appearing in >95% of all isolate genomes. The source of each genome (this study or others’) is indicated in red and gray. The 63 genomes from this study and 94 from others’ studies are indicated in red and gray, respectively. B The proportion of isolates from our isolate collection (63 in total) belong to each clade is plotted, in addition to the estimated relative abundance of each clade in the metagenome, as estimated using DiTASiC, which is showed as the percentage of total Segatella abundance. C Prevalence of Segatella clades in fecal metagenomes from Westernized and non-Westernized countries. Each dot denotes the prevalence of the Segatella clade in sample from each country. Error bars showing the standard errors. Categorization of the populations in (C) and (D) were provided by curatedMetagenomicData (cMD)²². D Probability distribution of the numbers of Segatella clades present in samples from Westernized or non-Westernized countries. The y-axis denotes the percentage of samples from each country. Error bars showing the standard errors. E A bar plot showing the percentages of each/all MAG genes identified in each isolate genome according to clade or all clades. F A bar plot showing the percentages of genes in each/all clade(s) that can be found in the MAGs.