Fig. 5: The expression of multiple genes involved in biofilm formation was significantly affected by punicalagin (PA) at 10 µg/mL in vitro. | npj Biofilms and Microbiomes

Fig. 5: The expression of multiple genes involved in biofilm formation was significantly affected by punicalagin (PA) at 10 µg/mL in vitro.

From: Exploiting strong synergies between punicalagin and cefoperazone to combat methicillin-resistant Staphylococcus aureus infections

Fig. 5

A Key genes involved in various stages of biofilm formation in the MRSA MW2 strain, particularly those cell-wall-associated genes. B The expression of five genes critical to bacterial attachment, clfB, fnbB, sdrD, sraP, and spa, was significantly downregulated, while the expression of agrB was significantly upregulated by PA. C The mRNA expression of pbp2, pbp3, pbp4, mecA, and murF was also significantly downregulated by PA. ***P < 0.001; **P < 0.01; *P < 0.05. The number represents the mean relative expression (or fold changes ± SD) of four replicates.

Back to article page