Fig. 11: Correlation analysis supporting the protective role of ADF mediated by the gut-brain axis. | npj Biofilms and Microbiomes

Fig. 11: Correlation analysis supporting the protective role of ADF mediated by the gut-brain axis.

From: Alternate-day fasting ameliorates α-synuclein pathology and suppresses inflammation via the gut-brain axis in an MPTP-induced subacute mouse model of Parkinson’s disease

Fig. 11

a Correlation between relative abundance of Alistipes and TH level in STR of mice. p = 0.0181, r = 0.6857. b Correlation between relative abundance of Alistipes and IL-18 level in SN of mice. p = 0.0449, r = −0.5822. c Correlation between relative abundance of Alistipes and IL-1β level in SN of mice. p = 0.0620, r = −0.5393. d Correlation between relative abundance of Helicobacter and TH level in STR of mice. p = 0.0019, r = −0.7474. e Correlation between relative abundance of Helicobacter and IL-18 level in SN of mice. p = 0.113, r = 0.4701. f Correlation between relative abundance of Helicobacter and IL-1β level in SN of mice. p = 0.0170, r = 0.5679. g Correlation between IL-18 level in gut and TH level in STR of mice. p = 0.0008, r = −0.8632. h Correlation between IL-18 level in gut and IL-18 level in SN of mice. p = 0.0002, r = 0.7243. i Correlation between IL-18 level in gut and IL-1β level in SN of mice. p = 0.0003, r = 0.7604. j Correlation between IL-1β level in gut and TH level in STR of mice. P=0.0449, r=0.-0.4271. k Correlation between IL-1β level in gut and IL-18 level in SN of mice. P=0.0098, r=0.4385. l Correlation between IL-1β level in gut and IL-1β level in SN of mice. P=0.0064, r=0.3708. (m) Correlation between the abundance of the Akkermansia, Helicobacter, Alistipes, Parabacteroides, Lactobacillus and TH level in STR, α-syn level in STR, IL-1β level in SN, IL-18 level in SN, IL-1β level in gut, IL-18 level in gut, NLRP3 level in SN, caspase1 level in SN of mice. The red lines represent a positive correlation, and the blue lines represent a negative correlation; The solid lines represent p<0.05, while the dashed lines represent p>0.05.

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