Table 5 Pearson correlation analysis between key differential microorganisms and metabolites

L-Glutamic acid

Ruminococcus_sp._Marseille-P6503

–0.7606

0.0041

0.0099

**

L-Glutamic acid

Alistipes_indistinctus

0.7406

0.0059

0.0370

**

L-Glutamic acid

Ruminococcaceae_bacterium_FB2012

–0.7154

0.0089

0.0222

**

L-Glutamic acid

Ruminococcus_sp._NK3A76

–0.7141

0.0091

0.0227

**

L-Glutamic acid

Clostridium_sp._CAG:571

–0.5954

0.0411

0.0964

*

L-Glutamic acid

Clostridium_sp._CAG:780

–0.6457

0.0233

0.1255

*

L-Glutamic acid

Ruminococcus_sp._CAG:579

–0.7752

0.0031

0.0110

**

5-Methoxy-DL-tryptophan

Ruminococcus_sp._Marseille-P6503

–0.6702

0.0171

0.0285

*

5-Methoxy-DL-tryptophan

Flavobacteriales_bacterium

0.8681

0.0003

0.0032

***

5-Methoxy-DL-tryptophan

Ruminococcaceae_bacterium_FB2012

–0.6112

0.0347

0.0480

*

5-Methoxy-DL-tryptophan

Ruminococcus_sp._NK3A76

–0.6590

0.0198

0.0359

*

5-Methoxy-DL-tryptophan

Parasutterella_sp._NM82_D38

0.9421

0.0000

0.0001

***

5-Methoxy-DL-tryptophan

Firmicutes_bacterium_CAG:103

–0.5783

0.0489

0.1138

*

5-Methoxy-DL-tryptophan

Parasutterella_excrementihominis

0.9388

0.0000

0.0001

***

5-Methoxy-DL-tryptophan

Ruminococcus_sp._CAG:579

–0.6658

0.0181

0.0279

*

Indoleacrylic acid

Ruminococcus_sp._Marseille-P6503

–0.8270

0.0009

0.0091

***

Indoleacrylic acid

Flavobacteriales_bacterium

0.6284

0.0286

0.0337

*

Indoleacrylic acid

Ruminococcaceae_bacterium_FB2012

–0.7633

0.0039

0.0222

**

Indoleacrylic acid

Ruminococcus_sp._NK3A76

–0.7860

0.0024

0.0227

**

Indoleacrylic acid

Parasutterella_sp._NM82_D38

0.8171

0.0012

0.0059

**

Indoleacrylic acid

Clostridium_sp._CAG:571

–0.6264

0.0293

0.0964

*

Indoleacrylic acid

Parasutterella_excrementihominis

0.8064

0.0015

0.0077

**

Indoleacrylic acid

Roseburia_inulinivorans

0.7814

0.0027

0.0538

**

Indoleacrylic acid

Ruminococcus_sp._CAG:579

–0.7112

0.0095

0.0160

**

Cyclo(D-trp-D-asp-pro-D-val-leu)

Bacteroidales_bacterium

–0.5948

0.0414

0.1046

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Clostridium_sp._CAG:710

0.6235

0.0303

0.1483

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Ruminococcus_sp._Marseille-P6503

0.6043

0.0374

0.0448

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Clostridium_sp._CAG:452

0.7587

0.0042

0.0845

**

Cyclo(D-trp-D-asp-pro-D-val-leu)

Alistipes_indistinctus

–0.6695

0.0173

0.0416

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Duncaniella_freteri

–0.7533

0.0047

0.0312

**

Cyclo(D-trp-D-asp-pro-D-val-leu)

Bacteroides_ovatus

–0.6098

0.0353

0.1678

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Flavobacteriales_bacterium

–0.7696

0.0034

0.0076

**

Cyclo(D-trp-D-asp-pro-D-val-leu)

Ruminococcaceae_bacterium_FB2012

0.6195

0.0317

0.0480

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Ruminococcus_sp._NK3A76

0.6035

0.0377

0.0539

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Parasutterella_sp._NM82_D38

–0.6633

0.0187

0.0340

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Clostridium_sp._CAG:417

0.5789

0.0486

0.3062

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Clostridium_sp._CAG:571

0.5797

0.0482

0.0964

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Clostridium_sp._CAG:780

0.6258

0.0295

0.1255

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Firmicutes_bacterium_CAG:103

0.6704

0.0171

0.1138

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Parasutterella_excrementihominis

–0.6579

0.0201

0.0365

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Roseburia_inulinivorans

–0.6295

0.0283

0.0826

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Prevotella_copri

–0.6691

0.0173

0.0992

*

Cyclo(D-trp-D-asp-pro-D-val-leu)

Ruminococcus_sp._CAG:579

0.7969

0.0019

0.0106

**

Chenodeoxycholic acid 3-glucuronide

Ruminococcus_sp._Marseille-P6503

0.7380

0.0061

0.0123

**

Chenodeoxycholic acid 3-glucuronide

Alistipes_indistinctus

–0.6574

0.0202

0.0416

*

Chenodeoxycholic acid 3-glucuronide

Duncaniella_freteri

–0.6581

0.0200

0.0507

*

Chenodeoxycholic acid 3-glucuronide

Flavobacteriales_bacterium

–0.7863

0.0024

0.0069

**

Chenodeoxycholic acid 3-glucuronide

Ruminococcaceae_bacterium_FB2012

0.7214

0.0081

0.0222

**

Chenodeoxycholic acid 3-glucuronide

Ruminococcus_sp._NK3A76

0.7051

0.0104

0.0232

*

Chenodeoxycholic acid 3-glucuronide

Parasutterella_sp._NM82_D38

–0.6497

0.0222

0.0370

*

Chenodeoxycholic acid 3-glucuronide

Clostridium_sp._CAG:571

0.5804

0.0479

0.0964

*

Chenodeoxycholic acid 3-glucuronide

Parasutterella_excrementihominis

–0.6470

0.0230

0.0383

*

Chenodeoxycholic acid 3-glucuronide

Roseburia_inulinivorans

–0.5884

0.0441

0.0826

*

Chenodeoxycholic acid 3-glucuronide

Ruminococcus_sp._CAG:579

0.7299

0.0070

0.0141

**

Lithocholic acid glucuronide

Clostridium_sp._CAG:710

0.6032

0.0379

0.1483

*

Lithocholic acid glucuronide

Ruminococcus_sp._Marseille-P6503

0.6287

0.0285

0.0408

*

Lithocholic acid glucuronide

Duncaniella_freteri

–0.6468

0.0230

0.0511

*

Lithocholic acid glucuronide

Flavobacteriales_bacterium

–0.6928

0.0125

0.0179

*

Lithocholic acid glucuronide

Ruminococcaceae_bacterium_FB2012

0.6733

0.0164

0.0293

*

Lithocholic acid glucuronide

Ruminococcus_sp._NK3A76

0.6044

0.0374

0.0539

*

Lithocholic acid glucuronide

Ruminococcus_sp._CAG:579

0.5892

0.0438

0.0584

*

D-Citrulline

Ruminococcus_sp._Marseille-P6503

–0.6167

0.0327

0.0436

*

D-Citrulline

Alistipes_indistinctus

0.6546

0.0209

0.0416

*

D-Citrulline

Ruminococcaceae_bacterium_FB2012

–0.5787

0.0487

0.0609

*

D-Citrulline

Ruminococcus_sp._NK3A76

–0.5908

0.0431

0.0539

*

D-Citrulline

Clostridium_sp._CAG:780

–0.5821

0.0471

0.1255

*

Picolinic acid

Bacteroidales_bacterium

0.7829

0.0026

0.0277

**

Picolinic acid

Clostridiaceae_bacterium

–0.6519

0.0216

0.1702

*

Picolinic acid

Ruminococcus_sp._Marseille-P6503

–0.8936

0.0001

0.0018

***

Picolinic acid

Alistipes_indistinctus

0.7664

0.0036

0.0370

**

Picolinic acid

Duncaniella_freteri

0.7991

0.0018

0.0182

**

Picolinic acid

Bacteroides_ovatus

0.7036

0.0107

0.1363

*

Picolinic acid

Flavobacteriales_bacterium

0.8613

0.0003

0.0032

***

Picolinic acid

Ruminococcaceae_bacterium_FB2012

–0.8864

0.0001

0.0025

***

Picolinic acid

Ruminococcus_sp._NK3A76

–0.8794

0.0002

0.0033

***

Picolinic acid

Parasutterella_sp._NM82_D38

0.8442

0.0006

0.0037

***

Picolinic acid

Firmicutes_bacterium_CAG:103

–0.6185

0.0320

0.1138

*

Picolinic acid

Parasutterella_excrementihominis

0.8396

0.0006

0.0042

***

Picolinic acid

Roseburia_inulinivorans

0.7339

0.0066

0.0658

**

Picolinic acid

Prevotella_copri

0.7778

0.0029

0.0486

**

Picolinic acid

Ruminococcus_sp._CAG:579

–0.8696

0.0002

0.0048

***

Dihydroouabain

Bacteroidales_bacterium

–0.6242

0.0301

0.1046

*

Dihydroouabain

Ruminococcus_sp._Marseille-P6503

0.7863

0.0024

0.0097

**

Dihydroouabain

Clostridium_sp._CAG:452

0.6603

0.0194

0.1805

*

Dihydroouabain

Alistipes_indistinctus

–0.7230

0.0079

0.0370

**

Dihydroouabain

Duncaniella_freteri

–0.6100

0.0352

0.0640

*

Dihydroouabain

Bacteroides_ovatus

–0.6563

0.0204

0.1363

*

Dihydroouabain

Flavobacteriales_bacterium

–0.8445

0.0005

0.0037

***

Dihydroouabain

Ruminococcaceae_bacterium_FB2012

0.7079

0.0100

0.0222

**

Dihydroouabain

Ruminococcus_sp._NK3A76

0.7306

0.0070

0.0227

**

Dihydroouabain

Parasutterella_sp._NM82_D38

–0.7710

0.0033

0.0121

**

Dihydroouabain

Clostridium_sp._CAG:571

0.6962

0.0119

0.0964

*

Dihydroouabain

Clostridium_sp._CAG:780

0.7303

0.0070

0.0699

**

Dihydroouabain

Parasutterella_excrementihominis

–0.7705

0.0034

0.0112

**

Dihydroouabain

Roseburia_inulinivorans

–0.5819

0.0471

0.0826

*

Dihydroouabain

Prevotella_copri

–0.6587

0.0198

0.0992

*

Dihydroouabain

Ruminococcus_sp._CAG:579

0.8315

0.0008

0.0080

***

Peruvoside

Ruminococcus_sp._Marseille-P6503

0.7642

0.0038

0.0099

**

Peruvoside

Alistipes_indistinctus

–0.7129

0.0093

0.0370

**

Peruvoside

Duncaniella_freteri

-0.6577

0.0201

0.0507

*

Peruvoside

Flavobacteriales_bacterium

–0.8090

0.0014

0.0058

**

Peruvoside

Ruminococcaceae_bacterium_FB2012

0.7343

0.0065

0.0222

**

Peruvoside

Ruminococcus_sp._NK3A76

0.7207

0.0082

0.0227

**

Peruvoside

Parasutterella_sp._NM82_D38

–0.6940

0.0123

0.0308

*

Peruvoside

Clostridium_sp._CAG:571

0.6319

0.0275

0.0964

*

Peruvoside

Clostridium_sp._CAG:780

0.5954

0.0411

0.1255

*

Peruvoside

Parasutterella_excrementihominis

–0.6933

0.0124

0.0310

*

Peruvoside

Roseburia_inulinivorans

–0.6040

0.0375

0.0826

*

Peruvoside

Ruminococcus_sp._CAG:579

0.7716

0.0033

0.0110

**

Ursocholic acid

Clostridium_sp._CAG:452

0.6183

0.0321

0.1805

*

Ursocholic acid

Flavobacteriales_bacterium

–0.6721

0.0167

0.0208

*

Ursocholic acid

Firmicutes_bacterium_CAG:103

0.6006

0.0389

0.1138

*

PGE2-EA

Clostridium_sp._CAG:710

0.6101

0.0351

0.1483

*

PGE2-EA

Ruminococcus_sp._Marseille-P6503

0.8076

0.0015

0.0093

**

PGE2-EA

Alistipes_indistinctus

–0.6389

0.0253

0.0422

*

PGE2-EA

Bacteroides_ovatus

–0.5890

0.0439

0.1678

*

PGE2-EA

Flavobacteriales_bacterium

–0.7510

0.0049

0.0089

**

PGE2-EA

Ruminococcaceae_bacterium_FB2012

0.7250

0.0076

0.0222

**

PGE2-EA

Ruminococcus_sp._NK3A76

0.7299

0.0070

0.0227

**

PGE2-EA

Parasutterella_sp._NM82_D38

–0.7665

0.0036

0.0121

**

PGE2-EA

Clostridium_sp._CAG:417

0.5918

0.0426

0.3062

*

PGE2-EA

Clostridium_sp._CAG:571

0.7212

0.0081

0.0964

**

PGE2-EA

Clostridium_sp._CAG:780

0.7463

0.0053

0.0699

**

PGE2-EA

Parasutterella_excrementihominis

–0.7710

0.0033

0.0112

**

PGE2-EA

Roseburia_inulinivorans

–0.6759

0.0158

0.0826

*

PGE2-EA

Prevotella_copri

–0.6132

0.0340

0.1133

*

PGE2-EA

Ruminococcus_sp._CAG:579

0.7924

0.0021

0.0106

**

Cyclo(Leu-Phe)

Ruminococcus_sp._Marseille-P6503

0.7626

0.0039

0.0099

**

Cyclo(Leu-Phe)

Alistipes_indistinctus

–0.6734

0.0164

0.0416

*

Cyclo(Leu-Phe)

Duncaniella_freteri

–0.6569

0.0203

0.0507

*

Cyclo(Leu-Phe)

Flavobacteriales_bacterium

–0.7804

0.0027

0.0069

**

Cyclo(Leu-Phe)

Ruminococcaceae_bacterium_FB2012

0.7426

0.0057

0.0222

**

Cyclo(Leu-Phe)

Ruminococcus_sp._NK3A76

0.7230

0.0079

0.0227

**

Cyclo(Leu-Phe)

Parasutterella_sp._NM82_D38

–0.6666

0.0179

0.0340

*

Cyclo(Leu-Phe)

Clostridium_sp._CAG:571

0.6212

0.0311

0.0964

*

Cyclo(Leu-Phe)

Parasutterella_excrementihominis

–0.6648

0.0183

0.0365

*

Cyclo(Leu-Phe)

Roseburia_inulinivorans

–0.6317

0.0276

0.0826

*

Cyclo(Leu-Phe)

Ruminococcus_sp._CAG:579

0.7494

0.0050

0.0134

**

Pyridoxal

Flavobacteriales_bacterium

0.7139

0.0091

0.0152

**

Pyridoxal

Firmicutes_bacterium_CAG:103

–0.6667

0.0179

0.1138

*

Sphingosine-1-phosphocholine

Ruminococcus_sp._Marseille-P6503

0.7560

0.0044

0.0099

**

Sphingosine-1-phosphocholine

Alistipes_indistinctus

–0.7200

0.0083

0.0370

**

Sphingosine-1-phosphocholine

Duncaniella_freteri

–0.6598

0.0196

0.0507

*

Sphingosine-1-phosphocholine

Flavobacteriales_bacterium

–0.7829

0.0026

0.0069

**

Sphingosine-1-phosphocholine

Ruminococcaceae_bacterium_FB2012

0.7383

0.0061

0.0222

**

Sphingosine-1-phosphocholine

Ruminococcus_sp._NK3A76

0.7283

0.0072

0.0227

**

Sphingosine-1-phosphocholine

Parasutterella_sp._NM82_D38

–0.6714

0.0168

0.0340

*

Sphingosine-1-phosphocholine

Clostridium_sp._CAG:571

0.5805

0.0478

0.0964

*

Sphingosine-1-phosphocholine

Parasutterella_excrementihominis

–0.6713

0.0168

0.0365

*

Sphingosine-1-phosphocholine

Roseburia_inulinivorans

–0.5874

0.0446

0.0826

*

Sphingosine-1-phosphocholine

Ruminococcus_sp._CAG:579

0.7451

0.0054

0.0134

**

3a,6b,7b-Trihydroxy-5b-cholanoic acid

Flavobacteriales_bacterium

–0.6767

0.0157

0.0208

*

3a,6b,7b-Trihydroxy-5b-cholanoic acid

Firmicutes_bacterium_CAG:103

0.6429

0.0241

0.1138

*

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Bacteroidales_bacterium

0.7799

0.0028

0.0277

**

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Clostridiaceae_bacterium

–0.7099

0.0097

0.1702

**

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Ruminococcus_sp._Marseille-P6503

–0.6027

0.0380

0.0448

*

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Alistipes_indistinctus

0.6771

0.0156

0.0416

*

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Duncaniella_freteri

0.8123

0.0013

0.0182

**

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Bacteroides_ovatus

0.6761

0.0158

0.1363

*

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Flavobacteriales_bacterium

0.7084

0.0099

0.0153

**

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Ruminococcaceae_bacterium_FB2012

–0.6079

0.0360

0.0480

*

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Firmicutes_bacterium_CAG:103

–0.5989

0.0396

0.1138

*

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Prevotella_copri

0.7512

0.0049

0.0486

**

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone

Ruminococcus_sp._CAG:579

–0.7107

0.0096

0.0160

**

Nicotinamide N-oxide

Ruminococcus_sp._Marseille-P6503

–0.6484

0.0226

0.0347

*

Nicotinamide N-oxide

Flavobacteriales_bacterium

0.5941

0.0417

0.0463

*

Nicotinamide N-oxide

Ruminococcus_sp._NK3A76

–0.5951

0.0412

0.0539

*

Nicotinamide N-oxide

Parasutterella_sp._NM82_D38

0.8534

0.0004

0.0037

***

Nicotinamide N-oxide

Parasutterella_excrementihominis

0.8595

0.0003

0.0034

***

Nicotinamide N-oxide

Roseburia_inulinivorans

0.6701

0.0171

0.0826

*

Norhyocholic acid

Bacteroidales_bacterium

–0.6011

0.0387

0.1046

*

Norhyocholic acid

Clostridium_sp._CAG:710

0.6505

0.0220

0.1483

*

Norhyocholic acid

Ruminococcus_sp._Marseille-P6503

0.6945

0.0122

0.0222

*

Norhyocholic acid

Duncaniella_freteri

–0.6604

0.0194

0.0507

*

Norhyocholic acid

Flavobacteriales_bacterium

–0.7585

0.0042

0.0085

**

Norhyocholic acid

Ruminococcaceae_bacterium_FB2012

0.6681

0.0176

0.0293

*

Norhyocholic acid

Ruminococcus_sp._NK3A76

0.6203

0.0314

0.0523

*

Norhyocholic acid

Roseburia_inulinivorans

–0.6044

0.0374

0.0826

*

Norhyocholic acid

Prevotella_copri

–0.5800

0.0481

0.1170

*

Norhyocholic acid

Ruminococcus_sp._CAG:579

0.6564

0.0204

0.0292

*

Bufotalin

Bacteroidales_bacterium

–0.6240

0.0301

0.1046

*

Bufotalin

Clostridium_sp._CAG:710

0.5808

0.0477

0.1483

*

Bufotalin

Ruminococcus_sp._Marseille-P6503

0.7980

0.0019

0.0093

**

Bufotalin

Alistipes_indistinctus

–0.6474

0.0229

0.0416

*

Bufotalin

Duncaniella_freteri

–0.6345

0.0267

0.0533

*

Bufotalin

Flavobacteriales_bacterium

–0.8318

0.0008

0.0040

***

Bufotalin

Ruminococcaceae_bacterium_FB2012

0.6990

0.0114

0.0229

*

Bufotalin

Ruminococcus_sp._NK3A76

0.6831

0.0143

0.0287

*

Bufotalin

Parasutterella_sp._NM82_D38

–0.6937

0.0123

0.0308

*

Bufotalin

Clostridium_sp._CAG:571

0.6409

0.0247

0.0964

*

Bufotalin

Clostridium_sp._CAG:780

0.6144

0.0335

0.1255

*

Bufotalin

Parasutterella_excrementihominis

–0.6954

0.0120

0.0310

*

Bufotalin

Prevotella_copri

–0.6212

0.0311

0.1133

*

Bufotalin

Ruminococcus_sp._CAG:579

0.7392

0.0060

0.0134

**