Fig. 5: Heatmap based on Bray–Curtis Hierarchical Clustering showing three phylotypes of the paired endocervical, vaginal and rectal microbiomes for each of the three cohort datasets. | npj Biofilms and Microbiomes

Fig. 5: Heatmap based on Bray–Curtis Hierarchical Clustering showing three phylotypes of the paired endocervical, vaginal and rectal microbiomes for each of the three cohort datasets.

From: Azithromycin alters the microbiome composition, function and resistome in women with Chlamydia trachomatis infections

Fig. 5: Heatmap based on Bray–Curtis Hierarchical Clustering showing three phylotypes of the paired endocervical, vaginal and rectal microbiomes for each of the three cohort datasets.

The level of microbial sharing between microbiomes among the three anatomic sites is shown. The red horizontal lines separate the phylotypes within each cohort. The participant ID and the respective anatomic site are shown on the y-axis to the right of the heatmap (i.e., C, endocervix in red; V, vagina in red; R, rectum in blue; F, follow-up). The associated species are shown below each heatmap. Within-host genital to rectal (GRT; rectal samples in Phylotypes I or II; red arrows) or rectal to genital (RGT; endocervical or vaginal samples in Phylotypes III; orange arrows) transmission for each of the three cohort datasets at baseline and/or at follow-up can be appreciated (see also Fig. 6). The blue arrows denote complete or almost complete GRT transmissions of L. iners or G. vaginalis. The dendrograms were set at a distance threshold of 0.9 (see Methods).

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