Fig. 5: Community-level functional changes associated with infection status, stratified by country. | npj Biofilms and Microbiomes

Fig. 5: Community-level functional changes associated with infection status, stratified by country.

From: Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns

Fig. 5: Community-level functional changes associated with infection status, stratified by country.

A Venn diagram showing the enzyme commission (EC) numbers found in each study setting, stratified by infection status and showing the overlapping portion. B Non-metric multidimensional scaling (NMDS) plot based on the Bray-Curtis dissimilarity index applied to the EC abundance tables. Results from community comparisons using PERMANOVA and community dispersion using PERMDISP are shown, with significant results highlighted in bold. C Volcano plots based on comparison by infection status of normalized EC abundance tables using MaAsLin2, stratified by country. D Averaged Metacyc superclass abundance comparison by infection status stratified by country. E Fold-change abundance difference of Metacyc pathways between infected and uninfected patients calculated with MaAsLin2, stratified by country. F Fold-change (FC) comparison of Metacyc pathways associated with infection status between countries. To visualize the monotonic trend, we applied LOWESS smoothing (represented by colored triangles with black outlines) using a proportion of 0.6, balancing smoothness with the capture of local variations. IC Côte d’Ivoire, LA Laos, TA Tanzania.

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