Fig. 2: Gut microbiota changes are likely due to CORT treatment rather than prucalopride following a subchronic administration of the 5-HT4R agonist. | npj Biofilms and Microbiomes

Fig. 2: Gut microbiota changes are likely due to CORT treatment rather than prucalopride following a subchronic administration of the 5-HT4R agonist.

From: Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota

Fig. 2: Gut microbiota changes are likely due to CORT treatment rather than prucalopride following a subchronic administration of the 5-HT4R agonist.

A Alpha-diversity: Kruskal-Wallis test for Chao1 and Shannon not significant. B Beta-diversity, principal coordinate analysis of Bray-Curtis compiled distance matrix of all genera. C Microbiota changes at genus level. *p < 0.05 vs Veh/Veh and $p < 0.05 vs CORT/Veh. Data are expressed as median + min-to-max values (Veh/Veh n = 4, CORT/Veh n = 9, CORT/Flx n = 10, CORT/Pruca0.5 n = 10, CORT/Pruca1.5 n = 9). Data is analyzed using Kruskal-Wallis non-parametric test followed by Mann–Whitney U-test and corrected for multiple comparisons using the Benjamin-Hochberg false discovery rate (FDR) method.

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