Fig. 8: Bactericidal activity of ePICIrsaE in a murine mastitis model of S. aureus infection. | npj Biofilms and Microbiomes

Fig. 8: Bactericidal activity of ePICIrsaE in a murine mastitis model of S. aureus infection.

From: Targeted elimination of Staphylococcus aureus mastitis infections with synthetic phage-based CRISPR-Cas delivery systems

Fig. 8: Bactericidal activity of ePICIrsaE in a murine mastitis model of S. aureus infection.

A Schematic representation of the experimental design for the mouse mastitis model and the treatment regimen with PBS (negative control), vancomycin (positive control), and ePICIrsaE. B S. aureus V329, V329 Δbap, and V329 Δbap + ica bacterial counts from individual mammary glands following treatment with PBS, vancomycin, and ePICIrsaE. Each point represents one mammary gland; horizontal bars indicate mean values. Statistical significance was assessed using the Kruskal–Wallis test (ns no significant; *P < 0.05, **P < 0.01; ****P < 0.0001).

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